Background: Epidemiologic data on atopic diseases are scared. Different studies have shown that the burden of atopic diseases is
varying in space and time. Several factors are impacting on epidemiology of atopic in children. Among them, MMR vaccination has been
a topic of divergences.
Objective: To establish whether the MMR vaccination may influence the risk of atopic diseases in children.
Methods: We conducted electronic search terms included MESH or key words with “Atopic diseases” and “MMR vaccination” and
“Children”. Databases for peer-reviewed articles included Pub Med, CENTRAL, Scopus and CINAHL Plus. Additionally, Grey literature was
obtained from Google and WHO database.
Main results: Among 304 potentially relevant articles identified, 8 peer-reviewed articles met the inclusion criteria. Due to the
lack of standardized reporting of different outcomes and different study designs, we reported the results narratively based on P-value
and 95% CI. We found three studies that demonstrated that MMR vaccination increased the fold of asthma in children (P<0.05). In
contrast, two studies have approved that MMR vaccination is benefit in preventing asthma in children. MMR vaccination decreases
asthma respectively by OR 0.36 95%CI (0.14-0.91) and OR 0.96 95% CI (0.76-1.21). Two studies reported MMR vaccination increase
the eczema OR in two studies with respectively OR: 1.77 95% CI (1.20-2.61) and OR 1.86 95%CI (1.25-2.79). On the other hand, three
studies revealed that MMR vaccination did not have any effect on atopic eczema with respectively P=0.830, OR 0.94 95% CI (0.77-1.15)
and P=0.90.
Conclusion: Based on the variability between studies, we hypothesize that judging the association between MMR vaccination and
atopic diseases could not be fruitful in understanding different mechanisms. In this context, we suggested the interactions between
Gene-environment MMR vaccination and atopic diseases that could clarify divergences between the results.
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