Oculcutaneous Disease, Rosacea: Review Article - Lupine Publishers

Oculcutaneous Disease, Rosacea: Review Article by Amal O Al-Balbeesi in Theranostics of Respiratory & Skin Diseases- Lupine Publishers

Abstract: Ocular manifestations of rosacea are commonly nonspecific and variable. The etiology of the inflammation is not fully known and there is no definite diagnostic test for the disease. We often under diagnose the disease, despite the potential for serious sight threatening sequelae. When evaluating patients with rosacea, dermatologists and family physicians should obtain a careful history of eye complaints and examine the eyelid margins thoroughly. Patients with moderate-to-severe ocular findings will benefit from evaluation by an ophthalmologist. Controlling symptoms and preventing potential risk of blindness should be the aim of early diagnosis and prompt intervention. The mainstay of treatment is good lid hygiene, topical metronidazole, topical azithromycin eyedrops, topical cyclosporine, and oral tetracycline. The aim of this review is to shed light on the signs of ocular rosacea, dermatologists and family physicians must be familiar with, the understanding of the pathogenesis of this old disease of skin and the eye since the original observation by Von Arlt in 1864 and its treatment. 

https://www.lupinepublishers.com/respiratory-and-skin-journal/abstracts/oculcutaneous-disease-rosacea-review-article.ID.000107.php

https://www.lupinepublishers.com/respiratory-and-skin-journal/fulltext/oculcutaneous-disease-rosacea-review-article.ID.000107.php

https://www.lupinepublishers.com/respiratory-and-skin-journal/pdf/TRSD.MS.ID.000107.pdf

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Synthesis of C-6 Methyl Substituted Benzothiazole Derivatives and Antifungal Activity against Aspergillus Niger - Lupine Publishers

Synthesis of C-6 Methyl Substituted Benzothiazole Derivatives and Antifungal Activity against Aspergillus Niger by Akhilesh Gupta in Theranostics of Respiratory & Skin Diseases - Lupine Publishers

Abstract: Life-threatening illness occurs due to Aspergillus species cause a spectrum of disease ranging from airway colonization. In case of respiratory tract, aspergilloma is the most common form of pulmonary involvement, which is usually accompanied by preexisting lung disease finally architectural abnormalities most commonly stem from tuberculosis, although other associated conditions, such as sarcoidosis, bronchiectasis, and neoplasm, have been documented. Methodology: The present work comprised of synthesis and cyclization of substituted benzothiazole nucleus by reaction of substituted aniline with potassium thiocynate in presence of bromine in glacial acetic acid and ammonia under temperature control. Substituted benzothiazole then condensed with 2 (3 or 4)-nitrobenzoylchloride acid in presence of dry pyridine and acetone to get substituted nitrobenzamides. To the above product 2-nitroaniline, 3-nitroaniline, 4-nitroaniline in presence of DMF were treated to get newly synthesized derivatives (D-1 to D-09) through replacing at 7th position chlorine. Antifungal activity was performed against Aspergillus Niger by cup plate method (diffusion technique) using Griseoflavin as standard. Result: Among, all newly synthesized derivatives compound D-5 showed potent antifungal activity against activity. AspergillusNiger while compound D-6, D-8 and D-9 showed moderate inhibitory activity at both concentrations 50µg/ml and 100µg/ml as compared to standard. Conclusion: In the present work efforts have been made to synthesized newer derivatives having methyl substitution at C-6 position of benzothiazole while 2-(3 or 4)-aryl-NO2 considered as rotating substitution at C-2 and C-7 position of benzothiazole nucleus to find out influence of activity due to change in substitution position against Aspergillus Niger.

https://www.lupinepublishers.com/respiratory-and-skin-journal/abstracts/synthesis-of-c-6-methyl-substituted-benzothiazole-derivatives-and-antifungal-activity-against-aspergillus-niger.ID.000106.php

https://www.lupinepublishers.com/respiratory-and-skin-journal/fulltext/synthesis-of-c-6-methyl-substituted-benzothiazole-derivatives-and-antifungal-activity-against-aspergillus-niger.ID.000106.php 

https://www.lupinepublishers.com/respiratory-and-skin-journal/pdf/TRSD.MS.ID.000106.pdf

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Clinical Evaluation of Herbal Active Enriched Shampoo in Anti Dandruff Treatment - Lupine Publishers

Clinical Evaluation of Herbal Active EnrichedShampoo in Anti Dandruff Treatment by Sudhir Sawarkar in Theranostics of Respiratory & Skin Diseases- Lupine Publishers

The human scalp is susceptible to microbial build-up if not thoroughly and frequently washed with the appropriate cleansing agents such as shampoos. Natural oils are presented in our scalp and it called as a sebum and it is a fuel/food for the dandruff-causing microbe. Malassezia feeds off these oils, breaking it down into by products, including oleic acid; formation of oleic acid is a starting/ kick point of dandruff. Approximately 50% people in the world sensitive to the oleic acid and affected by the dandruff. Overall clinical study results revealed that usage of tested anti-dandruff shampoo is effective and significantly reduce the dandruff fungi in scalp. Efficacy was analyzed with changes in the intensity of dandruff over 6 weeks from baseline to treatment visits using VisualAnalogue Scale (VAS). The average response of Visual Analogue Scale for visit1 and visit 5 was 6.287 and 0.350 respectively. The average response/changes of Visual Analogue Scale score for Visit1 is 100.00 and Visit 2 having the score of 74.360; Visit 3 having the 47.924, Visit 4 having the score of 19.453 and Visit 5 was having the score of 5.567. It is concluded that there is statistically significant difference between the average response of Visual Analogue Score (VAS) between Visit 1 and Visit 5 which is indicative of remarkable improvement of dandruff over a period of 6 weeks. The tea tree oil in the formula act as a carrier to carry the actives in to the deeper part of the scalp; synergistic combination of natural and synthetic chemicals helps to control the dandruff. Overall study confirmed that the synergistic combination of synthetic anti-dandruff and natural ingredients plays a crucial role in control the anti-fungal, anti-inflammatory and local immune stimulatory actions.

https://www.lupinepublishers.com/respiratory-and-skin-journal/abstracts/clinical-evaluation-of-herbal-active-enriched-shampoo-in-anti-dandruff-treatment.ID.000105.php

https://www.lupinepublishers.com/respiratory-and-skin-journal/fulltext/clinical-evaluation-of-herbal-active-enriched-shampoo-in-anti-dandruff-treatment.ID.000105.php
https://www.lupinepublishers.com/respiratory-and-skin-journal/pdf/TRSD.MS.ID.000105.pdf

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